Metabolische Klassifikation von Prolaktinspiegeln
Quelle: Publikation: Macotela, Triebel, Clapp Time for a New Perspective on Prolactin in Metabolism Trends in Endocrinology and Metabolism, 2020
Continue readingAssociate Professor for Pathobiochemistry, General Hospital Nuremberg & Paracelsus Medical University Nuremberg, Institute for Clinical Chemistry, Laboratory Medicine and Transfusion Medicine
Quelle: Publikation: Macotela, Triebel, Clapp Time for a New Perspective on Prolactin in Metabolism Trends in Endocrinology and Metabolism, 2020
Continue readingThe pituitary hormone prolactin (PRL) regulates a variety of functions beyond reproduction. The association between physiological (pregnancy) and pathological (prolactinoma) hyperprolactinemia and metabolic alterations led to the concept of this hormone being diabetogenic. However, large cohort clinical studies have recently shown that low circulating PRL levels are associated with metabolic disease and represent a risk factor for type 2 diabetes (T2D), whereas high PRL levels are beneficial. Moreover, PRL acts on the pancreas, liver, adipose tissue, and hypothalamus to maintain and promote metabolic homeostasis. By integrating basic and clinical evidence, we hypothesize that upregulation of PRL levels is a mechanism to maintain metabolic homeostasis and, thus, propose that the range of PRL levels considered physiological should be expanded to higher values.
Continue readingOur clinical study protocol entitled “Basis and Design of a Randomized Clinical Trial to Evaluate the Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular
Continue readingThe role of vasoinhibin in biology and disease is evolving and its understanding requires the revision of its nomenclature, which is the purpose of this article: https://www.frontiersin.org/articles/10.3389/fendo.2019.00214/full
Continue readingThe so called “diabetic retinopathy” and the “diabetic macular edema” are two of the most frequent ocular diseases in patients with diabetes, and both feature pathologic changes of blood vessel
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