Metabolische Klassifikation von Prolaktinspiegeln
Quelle: Publikation: Macotela, Triebel, Clapp Time for a New Perspective on Prolactin in Metabolism Trends in Endocrinology and Metabolism, 2020
Continue readingAuthor: J. Triebel
Levosulpiride, Prolactin, and Vasoinhibin in Diabetic Retinopathy and Diabetic Macular Edema
Schematic representation of the mechanism by which levosulpiride therapy could limit the progression of diabetic macular edema and diabetic retinopathy. https://tvst.arvojournals.org/article.aspx?articleid=2770665
Continue readingMetabolic Classification of prolactin levels for patients with obesity and diabetes
The pituitary hormone prolactin (PRL) regulates a variety of functions beyond reproduction. The association between physiological (pregnancy) and pathological (prolactinoma) hyperprolactinemia and metabolic alterations led to the concept of this hormone being diabetogenic. However, large cohort clinical studies have recently shown that low circulating PRL levels are associated with metabolic disease and represent a risk factor for type 2 diabetes (T2D), whereas high PRL levels are beneficial. Moreover, PRL acts on the pancreas, liver, adipose tissue, and hypothalamus to maintain and promote metabolic homeostasis. By integrating basic and clinical evidence, we hypothesize that upregulation of PRL levels is a mechanism to maintain metabolic homeostasis and, thus, propose that the range of PRL levels considered physiological should be expanded to higher values.
Continue readingClinical Study on Prolactin/Vasoinhibin Axis in Diabetic Retinopathy
Our clinical study protocol entitled “Basis and Design of a Randomized Clinical Trial to Evaluate the Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular
Continue readingREGULATOR OF ANGIOGENESIS AND VASCULAR FUNCTION: A 2019 UPDATE OF THE VASOINHIBIN NOMENCLATURE
The role of vasoinhibin in biology and disease is evolving and its understanding requires the revision of its nomenclature, which is the purpose of this article: https://www.frontiersin.org/articles/10.3389/fendo.2019.00214/full
Continue readingVasoinhibin Three-dimensional Structure
Representation of the lowest energy structure of vasoinhibin Source: Robles, J. P., et al. (2018) Article on Journal Website http://creativecommons.org/licenses/by/4.0
Continue readingThree-dimensional Structure and Functional Domain of Vasoinhibin-Hormone Identified
Mexican and German scientists from the National University of Mexico (UNAM) and the Paracelsus Medical University Nuremberg publish study predicting the three-dimensional structure and functional domain of the vasoinhibin-hormone Patients
Continue readingDreidimensionale Struktur und funktioneller Bereich des Vasoinhibin-Hormons identifiziert
Mexikanische und deutsche Wissenschaftler der Nationalen Universität Mexikos (UNAM) und der Paracelsus Medizinischen Privatuniversität Nürnberg veröffentlichen Studie zur Struktur und Funktion des Vasoinhibin-Hormons Patienten mit Diabetes Mellitus leiden häufig an
Continue readingNeue medikamentöse Therapie zur Behandlung von diabetischen Augenerkrankungen in Erprobung
Bei der sogenannten diabetischen Retinopathie und dem diabetischen Makula-Ödem, zwei der häufigsten Augenschäden bei Patienten mit Diabetes, kommt es zu krankhaften Veränderungen der Durchblutung und der Blutgefäß-Funktionen in der Netzhaut.
Continue readingNew Pharmacological Treatment Against Diabetic Eye Diseases Is Tested
The so called “diabetic retinopathy” and the “diabetic macular edema” are two of the most frequent ocular diseases in patients with diabetes, and both feature pathologic changes of blood vessel
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